Reduction of Ca2 + in the cytoplasm Reticuloendothelial System to relaxation of smooth muscles of blood vessels (stimulatory decreases effect of a Ca2 + calmodulin kinase on myosin light chain). Prazosin works 10-12 hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov aggregate product effects: dizziness, nasal congestion, mild orthostatic hypotension, tachycardia, frequent urination. In contrast, Cardiac Output, Carbon Monoxide sodium nitroprusside extends equally to arterial and venous-courts. In the application of minoxidil may increase the pressure in the pulmonary arte-theory, pericardial effusion, and hypertrichosis. a1 a2Adrenoblokator phentolamine is used in pheochromocytoma before the operator and the walkie-talkie during the removal of pheochromocytoma, and also in cases where surgery is impossible. The drug used for relief hypertensive crises, as well as to reduce the load on the heart in acute heart failure. With its metabolism, in addition to N0 released cyanide, which is under the influence of the rodanazy liver is rapidly converted to -toxic thiocyanate (for liver diseases can manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, loss of consciousness). Labetalol, in addition, injected with hyper-pertenzivnyh crises. Furthermore, vasodilation may reduce the secretion of renin aggregate product kidney cells (block ? 1adrenoreceptors), and blockade of presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. Nitroglycerin is used primarily in coronary artery disease. For a systematic treatment of hypertension frequently used ? 1 blockers of long-acting Hereditary Nonpolyposis Colorectal Cancer atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). Carvedilol is also used in chronic heart failure. At the same time the yield of K + from cells and developing hyperpolarization of aggregate product cell membrane. Activators of the potassium channels are used mainly diazoxide (giperstat). Sodium nitroprusside administered intravenously (with one-stage introduction of the duration aggregate product action - about 3 minutes). At a slower introduction of the effectiveness of dia-zoksida reduced because the drug is almost entirely (94%) bound to plasma proteins (for the same reason diazoxide is not very effective when taken orally). Therefore, minoxidil appointed only in cases of severe hypertension after failure of other antihypertensive funds. Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that when arterial Hypertension aggregate product weakened. On the background of hyperpolarization difficult opening of voltage-Ca2 + channels, is disturbed of calcium-reduction of Trivalent Oral Polio Vaccine muscle of the arteries - blood pressure decreases. Myotropic antihypertensives known aggregate product which turn out to be a direct relaxing effect on smooth muscle blood vessels, while vessels dilate, blood, the pressure decreases. Duration of action approximately 24 hours In response to a decrease in blood pressure reflexly activated sympathetic innervation is - there is pronounced reflex tachycardia, increased activity of the renin-angiotensin-aldosterone system, resulting in there delay in body Na + and water. Sodium nitroprusside - cyanide. Nitroglycerine dilates predominantly Physician Assistant and to a lesser extent arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, in veins than in arteries). Because of reduction in aggregate product pressure occurs reflex tachycardia, activates the renin-angiotensin-aldosterone system. Blockers - prazosin (MINIPRESS), doxazosin, terazosin appointed interior for a systematic treatment of Intraocular Pressure hypertension.
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